Sabtu, 30 Agustus 2014

[R649.Ebook] Free PDF The Cure at Troy: A Version of Sophocles' Philoctetes, by Seamus Heaney

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The Cure at Troy: A Version of Sophocles' Philoctetes, by Seamus Heaney

The Cure at Troy is Seamus Heaney's version of Sophocles' Philoctetes. Written in the fifth century BC, this play concerns the predicament of the outcast hero, Philoctetes, whom the Greeks marooned on the island of Lemnos and forgot about until the closing stages of the Siege of Troy. Abandoned because of a wounded foot, Philoctetes nevertheless possesses an invincible bow without which the Greeks cannot win the Trojan War. They are forced to return to Lemnos and seek out Philoctetes' support in a drama that explores the conflict between personal integrity and political expediency.

Heaney's version of Philoctetes is a fast-paced, brilliant work ideally suited to the stage. Heaney holds on to the majesty of the Greek original, but manages to give his verse the flavor of Irish speech and context.

  • Sales Rank: #164920 in Books
  • Published on: 1991-12-04
  • Released on: 1991-12-04
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.20" h x .26" w x 5.47" l, .27 pounds
  • Binding: Paperback
  • 96 pages

Review
“A purifying play, in the great tradition of modern Irish drama: think of Synge's Playboy of the Western World, O'Casey's early work, or even some of Yeats's Cuchulain plays.” ―John Peters, The Sunday Times (London)

About the Author
Seamus Heaney (1939-2013) received the Nobel Prize in Literature in 1995. His poems, plays, translations, and essays include Opened Ground, Electric Light, Beowulf, The Spirit Level, District and Circle, and Finders Keepers. Robert Lowell praised Heaney as the "most important Irish poet since Yeats."

Most helpful customer reviews

0 of 0 people found the following review helpful.
A translation that invigorates an ancient and obtuse play
By Michael Boyajian
The late Seamus Heaney takes an obtuse ancient Greek play and makes it into something readily understandable to modern readers as an indispensable part of the fragmented Trojan War saga.

0 of 0 people found the following review helpful.
am glad to have Heaney's wonderful retelling of the tale
By Amazon Customer
I didn't know the original Greek story; am glad to have Heaney's wonderful retelling of the tale.

24 of 26 people found the following review helpful.
The Cure at Troy yields a measured dose
By Debbie East
Seamus Heaney's version of trials for the Greek archer entrusted with Hercules' infallible bow and arrows gives us affirmation and points of reflection. Heaney does not dash the ancient dialogue style on the rocky island; rather it is enriched for the modern reader. Honoring the timelessness of Sophocles, Heaney allows today's reader to make comparisons of private nature and choices with the public need and will. The hero, Achilles' son, Neoptolemus, finds that the strategy to take Troy for the Greeks runs counter to his nature of honesty and integrity. We wrestle with him over the choices. We tumble with him when he loses his grip. We crawl back to sure footing along side the hero. I found myself understanding the characters based on different experiences in my life. Philoctetes bemoans his ill-fated injury which leaves him abandoned and full of vengeance. Human empathy allows him to examine his tight grip on his woundedness without denying what he has endured. Odysseus, the pragmatic lieutenant of war, is shown for his utility and foibles. As in all Greek plays, the chorus calls the characters and the reader to reflection, "...For my part is the chorus, and the chorus is more or less a borderline between the you and the me and the it of it." Heaney got the "it of it" for us to take our own measure.

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Jumat, 29 Agustus 2014

[R720.Ebook] Download Ebook C# Precisely (MIT Press), by Peter Sestoft, Henrik I. Hansen

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C# Precisely (MIT Press), by Peter Sestoft, Henrik I. Hansen

C# is an object-oriented programming language that is similar to Java in many respects but more comprehensive and different in most details. This book offers a quick and accessible reference for anyone who wants to know C# in more detail than that provided by a standard textbook. It will be particularly useful for C# learners who are familiar with Java. This second edition has been updated and expanded, reflecting the evolution and extension of the C# programming language. It covers C# versions 3.0 and 4.0 and takes a look ahead at some of the innovations of version 5.0. In particular, it describes asynchronous programming as found in 5.0.

Despite the new material, C# Precisely remains compact and easy to navigate. It describes C# in detail but informally and concisely, presenting lambda expressions, extension methods, anonymous object expressions, object initializers, collection initializers, local variable type inference, type dynamic, type parameter covariance and contravariance, and Linq (language integrated query), among other topics, all in aabout 250 pages. The book offers more than 250 examples to illustrate both common use and subtle points. Two-page spreads show general rules on the left and relevant examples on the right, maximizing the amount of information accessible at a glance.

The complete, ready-to-run example programs are available at the book's Web site, http://www.itu.dk/people/sestoft/csharpprecisely/

  • Sales Rank: #1235150 in Books
  • Published on: 2011-11-18
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .50" w x 8.00" l, 1.09 pounds
  • Binding: Paperback
  • 264 pages

Review

Praise for the first edition: Blaise Pascal once wrote, 'I have made this letter longer than usual, because I lack the time to make it short.' Peter Sestoft and Henrik Hansen have taken the time to write a short book on C# that leaves nothing out.

(Anders Hejlsberg, Microsoft Corporation)

A book such as this should always be close at hand, both for experts and for those who have some prior programming experience when tackling a problem.

(Mathew Burns Times Higher Education)

About the Author

Peter Sestoft is Professor of Software Development at the IT University of Copenhagen, Denmark. He is the author of Java Precisely (second edition, MIT Press, 2005). Henrik I. Hansen holds master's degrees in information technology and chemistry.

Most helpful customer reviews

2 of 2 people found the following review helpful.
Good reference
By Jaewoo Kim
This is a good reference for the C# developers who want to get a good overview of the C# framework and architecture.

Every time I read a book like this, I ask myself "will this book improve my programming skills and understanding?"

I am certain this book will improve programming understanding for everyone. Yet, I am not sure if it will really improve programming skills. The book has no programming exercises that helps the reader to inculcate the knowledge contained in this book into a solid learning experience.

Furthermore, the book doesn't get too much into algorithms. I can't say this is the best C# book I have ever read. But I can still recommend this book based on high quality writing and knowledge about practical C# programming explanations.

Pros:
1)Good explanations of C# framework and architecture.
2)Short and succinct.
3)Good programmatic examples.

Cons:
1)No programming exercises.
2)Very light on programmatic algorithms.

0 of 2 people found the following review helpful.
Great book!
By WDP
Excellent book! It's full of very useful and practical information.

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Kamis, 28 Agustus 2014

[Z485.Ebook] Free PDF Medici Women: Portraits of Power, Love, and Betrayal in the Court of Duke Cosimo I, by Gabrielle Langdon

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Medici Women: Portraits of Power, Love, and Betrayal in the Court of Duke Cosimo I, by Gabrielle Langdon

Medici Women: Portraits of Power, Love, and Betrayal in the Court of Duke Cosimo I, by Gabrielle Langdon



Medici Women: Portraits of Power, Love, and Betrayal in the Court of Duke Cosimo I, by Gabrielle Langdon

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Medici Women: Portraits of Power, Love, and Betrayal in the Court of Duke Cosimo I, by Gabrielle Langdon

The ducal court of Cosimo I de' Medici in sixteenth-century Florence was one of absolutist, rule-bound order. Portraiture especially served the dynastic pretensions of the absolutist ruler, Duke Cosimo and his consort, Eleonora di Toledo, and was part of a Herculean programme of propaganda to establish legitimacy and prestige for the new sixteenth-century Florentine court.

In this engaging and original study, Gabrielle Langdon analyses selected portraits of women by Jacopo Pontormo, Agnolo Bronzino, Alessandro Allori, and other masters. She defines their function as works of art, as dynastic declarations, and as encoded documents of court culture and propaganda, illuminating Cosimo's conscious fashioning of his court portraiture in imitation of the great courts of Europe. Langdon explores the use of portraiture as a vehicle to express Medici political policy, such as with Cosimo's Hapsburg and Papal alliances in his bid to be made Grand Duke with hegemony over rival Italian princes.

Stories from archives, letters, diaries, chronicles, and secret ambassadorial briefs, open up a world of fascinating, personalities, personal triumphs, human frailty, rumour, intrigue, and appalling tragedies. Lavishly illustrated, Medici Women: Portraits of Power, Love and Betrayal in the Court of Duke Cosimo I is an indispensable work for anyone with a passion for Italian renaissance history, art, and court culture.

  • Sales Rank: #1646086 in Books
  • Published on: 2007-09-29
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.71" h x 1.15" w x 6.77" l, 1.91 pounds
  • Binding: Paperback
  • 480 pages

Most helpful customer reviews

9 of 9 people found the following review helpful.
An outstanding work of scholarship in Renaissance portraits
By K. Maxwell
Even if you have read other books on Renaissance painting you are bound to lean a lot by reading this one. This is a very academic overview of the paintings of Medici women in Florence during the reign of Cosimo 1st. The centrepiece portraits are those done by Bronzino with the portrait of Duchess Eleonora and her son Giovanni given a whole chapter to itself.

The author brings an impressive depth of scholarship to this book - and outlines the social and intellectual expectations that are encoded within these somewhat seemingly simple portraits. There are layers of meaning in these paintings - even the most simple looking - that would have been read by contemporary viewers but have been lost to modern viewers as society has changed.

Half this book is references and the author has extensively footnoted her sources. These a selection of colour images at the front of the book of the central portraits discussed and sections of black and white images of other portraits that are used on a comparison basis. This is not a picture book as such, but you'll learn a lot by reading it and the paintings in the colour section will quite literally come alive for you after you have read their subjects backgrounds and meanings painted within them. This book is highly recommended if you want an in-depth understanding of Florentine women's portraits in the 16th century, but it will be a disappointment if you are looking for a large selection of colour images of Medici women.

7 of 7 people found the following review helpful.
An exquisite and erudite study
By Mary
This magnificent book displays the best of the art history AND history being written today. Gabrielle Langdon's years of research and writing have paid off in a study that offers new evidence about one of the most significant periods of Florentine history (the sixteenth century) and about one of its most fabled dynasties, the Medici. She furnishes well-researched accounts of the major artists working in Florence at the time, and she demonstrates a breath-taking command of the ample theoretical material on topics such as iconography, artistic restoration, gender studies, and issues of race in history.
Langdon has been instrumental in uncovering the importance of Alessandro de' Medici and his progeny for Florentine history, as his brief reign as Duke of Florence has not been scrutinized sufficiently by modern historians. Alessandro's African (or "moorish") ancestry is a crucial aspect of Langdon's study, and it is refreshing to see this topic dealt with in a sensitive manner. Together with some forthcoming research by Professor John Brackett on Alessandro, we will soon have a better picture of a complex, violent, and crucial phase of European history.
A final comment: Langdon is a scrupulous researcher, whose copious notes demonstrate her command of the literature of this period, but she is also a gracious scholar, who pays tribute to the work of others and presents differences of opinion in an even-handed and non-acrimonious manner.
This is one of the best books I have read in the last ten years.

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Senin, 25 Agustus 2014

[O201.Ebook] Ebook Free Electromagnetism (Manchester Physics Series), by I. S. Grant, W. R. Phillips

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Electromagnetism (Manchester Physics Series), by I. S. Grant, W. R. Phillips

The Manchester Physics Series General Editors: D. J. Sandiford; F. Mandl; A. C. Phillips Department of Physics and Astronomy, University of Manchester Properties of Matter B. H. Flowers and E. Mendoza Optics Second Edition F. G. Smith and J. H. Thomson Statistical Physics Second Edition F. Mandl Electromagnetism Second Edition I. S. Grant and W. R. Phillips Statistics R. J. Barlow Solid State Physics Second Edition J. R. Hook and H. E. Hall Quantum Mechanics F. Mandl Particle Physics Second Edition B. R. Martin and G. Shaw the Physics of Stars Second Edition A. C. Phillips Computing for Scientists R. J. Barlow and A. R. Barnett Electromagnetism, Second Edition is suitable for a first course in electromagnetism, whilst also covering many topics frequently encountered in later courses. The material has been carefully arranged and allows for flexi-bility in its use for courses of different length and structure. A knowledge of calculus and an elementary knowledge of vectors is assumed, but the mathematical properties of the differential vector operators are described in sufficient detail for an introductory course, and their physical significance in the context of electromagnetism is emphasised. In this Second Edition the authors give a fuller treatment of circuit analysis and include a discussion of the dispersion of electromagnetic waves. Electromagnetism, Second Edition features:

  • The application of the laws of electromagnetism to practical problems such as the behaviour of antennas, transmission lines and transformers.
  • Sets of problems at the end of each chapter to help student understanding, with hints and solutions to the problems given at the end of the book.
  • Optional "starred" sections containing more specialised and advanced material for the more ambitious reader.
  • An Appendix with a thorough discussion of electromagnetic standards and units.

Recommended by many institutions. Electromagnetism. Second Edition has also been adopted by the Open University as the course book for its third level course on electromagnetism.

  • Sales Rank: #1713512 in eBooks
  • Published on: 2013-06-05
  • Released on: 2013-06-05
  • Format: Kindle eBook

From the Publisher
Revised and updated, this work continues to explore the field of electromagnetism, presenting selected topics in a concise, instructive and stimulating way for students of physics. Arranged logically, early chapters cover such topics as electric charge, Gauss' law, polarization, electrostatic field calculations, the magnetic field and magnetic dipole, Ampere's law and magnetic materials. Later chapters examine electromagnetic induction, networks, filters, alternating currents and transients, Maxwell's equations and waveguides. Also included are end-of-chapter problems with answers at the back of the book.

From the Back Cover
The Manchester Physics Series General Editors: D. J. Sandiford; F. Mandl; A. C. Phillips Department of Physics and Astronomy, University of Manchester Properties of Matter B. H. Flowers and E. Mendoza Optics Second Edition F. G. Smith and J. H. Thomson Statistical Physics Second Edition F. Mandl Electromagnetism Second Edition I. S. Grant and W. R. Phillips Statistics R. J. Barlow Solid State Physics Second Edition J. R. Hook and H. E. Hall Quantum Mechanics F. Mandl Particle Physics Second Edition B. R. Martin and G. Shaw the Physics of Stars Second Edition A. C. Phillips Computing for Scientists R. J. Barlow and A. R. Barnett Electromagnetism, Second Edition is suitable for a first course in electromagnetism, whilst also covering many topics frequently encountered in later courses. The material has been carefully arranged and allows for flexi-bility in its use for courses of different length and structure. A knowledge of calculus and an elementary knowledge of vectors is assumed, but the mathematical properties of the differential vector operators are described in sufficient detail for an introductory course, and their physical significance in the context of electromagnetism is emphasised. In this Second Edition the authors give a fuller treatment of circuit analysis and include a discussion of the dispersion of electromagnetic waves. Electromagnetism, Second Edition features:

  • The application of the laws of electromagnetism to practical problems such as the behaviour of antennas, transmission lines and transformers.
  • Sets of problems at the end of each chapter to help student understanding, with hints and solutions to the problems given at the end of the book.
  • Optional "starred" sections containing more specialised and advanced material for the more ambitious reader.
  • An Appendix with a thorough discussion of electromagnetic standards and units.
Recommended by many institutions. Electromagnetism. Second Edition has also been adopted by the Open University as the course book for its third level course on electromagnetism.

Most helpful customer reviews

8 of 8 people found the following review helpful.
Excellent, Readable! Like Physics ought to be!
By A Customer
The text is lucid in its presentation of what is often viewed as a difficult subject.
Starting with no more than a sound understanding of sixth form (high school) Mathematics and Physics, the authors proceed to underpin elementary concepts of electrostatics, simple circuits, and magnetism with the rigour and completeness demanded at University level. New mathematical ideas are introduced gently (so naturally, in fact, that the reader does not feel that (s)he is being asked to learn some new things!) and blended into the key Physical concepts.
The book accelerates through a whole lot of material and tacitly introduces the reader to Maxwell's Equations without calling them so. Only after all of the core physical concepts - Dielectrics, Steady Currents and Magnetic Fields, Ferromagnetism, Electromagnetism/Induction - have been covered, do the authors venture to integrate the mathematics into Maxwell's equations. This emphasis on the Physics (with the Mathematics working merely as a tool) works really well and is central to the readability of this book.
The latter chapters explore Transmission Lines, Electromagnetic Waves (which the mathematically inclined texts like to boast about as solutions of Maxwell's Equations), and the beginnings of Relativistic Electrodynamics.
All in all, an excellent, enjoyable book - highly recommended! Makes Physics fun!
Lastly, I might add that I was one of the "guinea pigs" at Manchester who benefited directly from the materials in this book and others in the Manchester Physics Series.

5 of 5 people found the following review helpful.
Excelent Introductory Text
By A Customer
I had to read this book cover to cover for E.M. class and I found it's layout and presentation very well done. Excelent review of magnetostatics, electrostatics, H & D fields, Maxwell's Eqns, etc. In conjuntion with E.M. Fields and Waves by Lorrain, provides all the necessary texts needed for undergradute courses in E.M.

4 of 4 people found the following review helpful.
Readable, Enjoyable! Like Physics ought to be!
By A Customer
The text is lucid in its presentation of what is often viewed as a difficult subject.
Starting with no more than a sound understanding of sixth form (high school) Mathematics and Physics, the authors proceed to underpin elementary concepts of electrostatics, simple circuits, and magnetism with the rigour and completeness demanded at University level. New mathematical ideas are introduced gently (so naturally, in fact, that the reader does not feel that (s)he is being asked to learn some new things!) and blended into the key Physical concepts.
The book accelerates through a whole lot of material and tacitly introduces the reader to Maxwell's Equations without calling them so. Only after all of the core physical concepts - Dielectrics, Steady Currents and Magnetic Fields, Ferromagnetism, Electromagnetism/Induction - have been covered, do the authors venture to integrate the mathematics into Maxwell's equations. This emphasis on the Physics (with the Mathematics working merely as a tool) works really well and is central to the readability of this book.
The latter chapters explore Transmission Lines, Electromagnetic Waves (which the mathematically inclined texts like to boast about as solutions of Maxwell's Equations), and the beginnings of Relativistic Electrodynamics.
All in all, an excellent, enjoyable book - highly recommended! Makes Physics fun!
Lastly, I might add that I was one of the "guinea pigs" at Manchester who benefited directly from the materials in this book and others in the Manchester Physics Series.

See all 8 customer reviews...

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Kamis, 21 Agustus 2014

[U680.Ebook] Ebook Free Irish Myth, Lore and Legend on Film (Reimagining Ireland), by Dawn Duncan

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Irish Myth, Lore and Legend on Film (Reimagining Ireland), by Dawn Duncan

This book examines film versions of Irish myth, lore, and legend, concentrating particularly on stories which encompass the life journey of the hero, as proposed by Carl Jung and adapted by Joseph Campbell. After establishing the usefulness of film as cultural critique, the author provides intertextual and comparative readings of a number of films which follow a hero’s journey. The stages of this journey include the child’s struggle to achieve identity and become a responsible member of the community, the adult’s ability to move beyond the self and fall in love with another, and the community member’s willingness to sacrifice self in the service of Ireland. In addition, the study examines the lore of matchmaking and the communal uses of legend creation, as well as providing an ironic reading of the heroic journey through an exploration of the contemporary anti-hero. The films analysed include Into the West, The Secret of Roan Inish, In America, The Quiet Man, The Matchmaker, Michael Collins, The Wind That Shakes the Barley, Veronica Guerin, and In Bruges.

  • Sales Rank: #2389317 in Books
  • Published on: 2012-12-11
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.75" h x 5.75" w x .50" l, .60 pounds
  • Binding: Paperback
  • 171 pages

Review
-There is much to recommend in this volume. Passionately written, humanistic in spirit, entertaining as text, and academic in approach, 'Irish Myth, Lore and Legend on Film' offers a new scholarly toolkit for those in the field of interdisciplinary studies: it considers film as cultural writing; is anchored by psycho-anthropological theory; and is embedded in historical context.- (Beatriz Kopschitz Bastos, Estudios Irlandeses 9, 2014)"

About the Author
Dawn Duncan is Professor of English at Concordia College-Moorhead, Minnesota, USA, where she also teaches in the interdisciplinary Global Studies and Film Studies programs. She serves as the Executive Secretary of the International Association for the Study of Irish Literatures. In addition to numerous essays on Irish drama, fiction, and film, she is the author of two books: Postcolonial Theory in Irish Drama from 1800-2000 and The Service-Learning Companion.

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Rabu, 20 Agustus 2014

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Bad Moon Rising, by Thomas M Disch

  • Sales Rank: #4171304 in Books
  • Published on: 1973
  • Ingredients: Example Ingredients
  • Number of items: 1
  • Binding: Hardcover
  • 302 pages

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Selasa, 19 Agustus 2014

[H587.Ebook] Ebook Download Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg

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Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg

This book aims to make the readers better informed and more critical consumers of clinical research. It will help the reader recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. Cartoons make the text easier to read and generate a few laughs, and they underscore specific points, sometimes in a provocative way.

  • Sales Rank: #1608571 in Books
  • Published on: 2010-06-02
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x .40" w x 6.10" l, .56 pounds
  • Binding: Paperback
  • 165 pages

Review

From the reviews of the second edition:

"Evaluating Clinical Research is simply the best introductory book of the science of clinical research you can read in two hours. The title grossly understates the appropriate readership; every new investigator and clinical research professional should start with this book." (Norman M. Goldfarb, Journal of Clinical Research Best Practices, Vol. 6, No. 1, January 2010)

"Evaluating Clinical Research is only 161 pages in length and contains 26 chapters. … Students have found the book clearly written and logical to follow. Faculty members who have purchased this textbook have commented on the usefulness of the book in brushing up on literature evaluation topics … . In summary, Evaluating Clinical Research, 2nd ed, can be recommended as a required textbook for drug information courses and a refresher text for pharmacy practice faculty members." (Larry Sasich, American Journal of Pharmaceutical Education, Vol. 72 (2), 2008)

"Authors provide tools to evaluate pros and cons of these studies in order to distinguish worthwhile from flawed. . . . . A readable and informative book that provides valuable insight into an important segment of our medical system. . . . Authors have included many humorous cartoons that underscore specific points in a provocative way. There also is a handy glossary of terms connected with clinical studies." (Douglas C. Borton, Actuarial Digest, Spring ed., 2008)

"The authors not only cover most of the major concepts required to evaluate clinical research literature, but also manage to address more nuanced concepts such as intermediate and composite end points and meta-analysis. . . . A particular strength of this book is that the authors end the book with a resource-rich chapter listing available literature databases and a straighforward checklist of issues. . . ." (Rachel Wildman, American Journal of Hypertension, Vol. 21, Novmeber 2008)

"Readership: Health care professionals, pharmaceutical company employees, and others who wish to be able to understand the … clinical studies. … Its aim is to enable a non-statistical reader to distinguish sound methodology from weak methodology in clinical trials. This is a highly laudable and valuable aim. Moreover, the book has the merit of containing no mathematics or statistics … to appeal to the intended audience. It also has the merit of being short … to be read by the busy health care workers." (David J. Hand, International Statistical Review, Vol. 76 (1), 2008)

"Doctors prescribe inefficiently. Many conditions, such as hypertension, are inadequately treated whereas others, such as depression, are overtreated. Bearing in mind the plethora of guidelines now available on virtually every sector of medicine, this seems inexcusable. Whether due to ignorance, indolence, or incredulity, many physicians are not implementing the recommendations of 'experts'.

Conscientious clinicians may think that the advice available from the 'experts' does not apply to the patients they see and will want to assess the evidence for themselves, so that their practice will provide the best management for their patients. It is for such people that this book has been written. The writing is excellent and it is embellished by amusing cartoons and witty one-line quotations. The authors have tried, but not completely succeeded, in avoiding statistics. Their extensive personal experience has enabled them to give good examples to illustrate their points, although they also quote widely from the world literature.

They start by emphasizing the importance of evaluating the balance between benefit and harm. Unfortunately, all too often, papers and presentations, as well as pharmaceutical companies, often highlight the benefits of new treatments while saying little about the adverse effects.

The value of randomized controlled trials (RCTs) as the bedrock of evidence-based medicine is unquestionable, but the shortcomings are often ignored-especially by 'experts'. The authors discuss both the strengths and weaknesses of randomized RCTs. The chapter on weaknesses is largely concerned with the inability of RCTs, because of their limited size, to recognize rare side effects. Although referred to later in the book, the unrepresentative nature of those recruited into trials is given insufficient attention. This is a major reason why practising physicians are often sceptical about the results of trials.

Having stressed that RCTs 'rank highly in terms of reliability for evaluating treatments,' one may question the authors' claim that 'at the top of the ranking are meta-analyses of clinical trials'. In fact, as experience has shown, large individual trials may provide more convincing evidence than a meta-analysis.

In later chapters, they consider such important topics as the doubtful value of surrogate endpoints and biochemical markers, and they also discuss whether active controls can be relied upon and whether all drugs in a class are interchangeable. Much attention is paid to the measurement of adverse drug reactions but here, as elsewhere, discussion is focused on practices in the United States, whereas these issues are often better tackled in other countries (where many of their readers will be located).

Overall, this is an excellent book that can be strongly recommended to the target audience which is, as the authors state, ''clinicians and others in the health care field as well as employees in companies manufacturing drugs, devices and other medical products'." (Trials, Volume 9, 2008)

From the Back Cover

The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation.

There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way.

Bengt D. Furberg, MD, PhD is board-certified in internal medicine. After spending a decade as medical director in the pharmaceutical industry, he now serves as medical consultant, evaluating the safety and efficacy of pharmaceutical products and medical devices and promoting evidence-based medicine. His brother, Curt D. Furberg, MD, PhD, is Professor in the Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. After arriving in the United States from Sweden, he worked at the National Heart, Lung, and Blood Institute of the National Institutes of Health for 12 years. He is co-author of Fundamentals of Clinical Trials with Lawrence M. Friedman and David L. DeMets. His areas of interest are clinical trials, evidence-based medicine and drug safety. The authors have acquired much of their knowledge about clinical studies through the "trial and error" method. Thus, they have personal experience�with many of the problems they describe.

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0 of 1 people found the following review helpful.
Should be read by anyone considering...
By R. Taylor
...investing in biotechnology stocks...biotech stocks represent a minefield for investors...I would estimate at least 75% of biotech stocks are fraudulent in some fashion...in some cases, the fraud is nothing more than a conscious effort to swindle naive investors...in most others, however, it appears to arise out of sheer ignorance -- ignorance of basic scientific principles, ignorance of experimental design and statistics, etc...this ultimately manifests itself in the FDA's rejection of a large majority of phase 3 studies -- often to the dismay and financial distress of investors...the Furbergs' book provides a concise database of knowledge that will equip any reader with tools that will enable them to analyze clinical research...it's clearly written and, although it is somewhat technical, anyone with a high school background in science and math ought to be able to grasp the basic ideas...

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Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg PDF

Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg PDF

Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg PDF
Evaluating Clinical Research: All that glitters is not gold, by Bengt D. Furberg, Curt D. Furberg PDF